TMJ, Substance P, and Cancer

TMJ, Substance P, and Cancer:

substance P

Substance P molecule

Case histories suggest daily, ever stronger, that bite dysfunction with its sub-sequential elevated substance P through trigeminal nerve stimulation, is likely a major contributor to the development of many types of cancer.  This belief is based on a multitude of clinical observations and very strong medical literature.

Medical Literature:Substance P is known to be a major regulator of tumor cell proliferation (favoring tumor growth), angiogenesis, and migration of the tumor cells for invasion and metastasis (see article-particularly look at extensive references in article or abstract below).  The role of substance P in stem cell differentiation strongly suggests that bite dysfunction is likely cause of a large percentage of leukemias and lymphomas (see article or abstract below).

Case histories:

The incidence of breast cancer amongst my TMJ patients is very high.  Currently, I am providing optimal dental orthopedic therapy in conjunction with physician managed treatment for a number of other cancers with good early response.



Neurokinin-1 Receptor: A New Promising Target in the Treatment of Cancer

Published on October 8, 2010
Author: Miguel Muñoz
Specialty: Pediatrics
Institution: Research Laboratory on Neuropeptides, Hospital Infantil Universitario Virgen del Rocío
Address: Sevilla, 41013, Spain

Author: Rafael CoveñasSpecialty: Neuroscience
Institution: Laboratory of Neuroanatomy of the Peptidergic Systems, Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca
Address: Salamanca, 37007, Spain

Abstract: Substance P (SP) has a widespread distribution in the whole body. After binding to the neurokinin-1 (NK-1) receptor, SP regulates biological functions related to cancer: tumor cell proliferation (favoring tumor growth), angiogenesis, and migration of the tumor cells for invasion and metastasis. SP also exerts an antiapoptotic effect. The peptide is secreted from primary tumors and from peripheral nerves, and reaches the whole body through the blood stream. NK-1 receptors are overexpressed in tumors (cancer cells express more NK-1 receptors than normal cells). By contrast, after binding to NK-1 receptors, the NK-1 receptor antagonists specifically inhibit tumor cell proliferation (tumor cells die by apoptosis), angiogenesis and the migration of the tumor cells. Thus, 1) the SP/NK-1 receptor system plays an important role in the development of cancer, angiogenesis, and metastasis; 2) a common mechanism for cancer cell proliferation mediated by the SP/NK-1 receptor system occurs; 3) NK-1 receptor antagonists act as a broad-spectrum antitumoral agent; 4) the NK-1 receptor could be a new promising target in the treatment of cancer; 5) NK-1 receptor antagonists could improve cancer treatment — the development of antagonist molecules of the NK-1 receptor represents an important opportunity for exploiting these molecules as novel therapeutic agents.


Postepy Hig Med Dosw (Online). 2009 Mar 2;63:106-13.

[Substance P as a regulatory peptide of hematopoiesis and blood cell functions].

[Article in Polish]


Zakład Hematologii Eksperymentalnej, Instytut Zoologii Uniwersytetu Jagiellońskiego, Poland.


SP is an undecapeptide that belongs to the family of related neurokinins termed tachykinins. SP is one of the mediators responsible for the neural-immune/hematopoietic cross-talk. It is released from the nerve fibers of the autonomic and enteric nervous systems in lymphoid organs and is also produced by the resident, stromal or hematopoietic cells. SP stimulates the production of hematopoietic cytokines (e.g. IL-1, IL-3, IL-6, SCF, GM-CSF) by bone marrow stromal cells. It enhances the proliferation of bone marrow progenitors, both directly by binding to progenitor’s receptors and indirectly by interacting with marrow stromal cells. SP can also modulate immune and hematopoietic functions like phagocytosis, immunoglobulin production, lymphocyte proliferation and platelet aggregation. SP fragments derived from endopeptidase activity could also exert immune and hematopoietic regulation. The biological effects of SP are mediated through interactions with certain G protein-coupled receptors: the neurokinin (NK) receptors. Different studies have shown that NK receptors are localized on immuno-competent cells, including monocytes/macrophages, neutrophils, mast cells, dendritic cells and T or B lymphocytes, bone marrow stromal cells and hematopoietic progenitors. The disturbance of the neural-hematopoietic-immune axis may be implicated in hematological malignancies. SP seems to be important in the neoplastic transformation of bone marrow, leading to the development of acute leukaemia in children; myelofibrosis and also metastases to bone marrow of solid tumors in early stages of these diseases.

PMID:19252469  Free full text


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