The primary pathology created with a misaligned jaw is the elevation of “substance P” levels in the body. There is extensive literature demonstrating link between elevated substance P and irritable bowel syndrome (Substance P and Irritable Bowel).The effect of substance P is that it hypersensitizes all sensory neurons as well as strongly influences inflammation. Substance P is also a major mediator of intestinal motility (tachykinins and gut motility), thus causing spastic bowel function when it becomes elevated.
I have had many cases whose gut function that is dramatically changed with jaw alignment therapy. Substance P alters calcium transport on the cell membrane, thus increasing cell membrane permeability- i.e. leaky gut(gutsubstanceP). Substance P is also known to control migration of cells within the gut, thus altering healing ability(gutsubstanceP).
See also(neuropeptides in inflammatory bowel disease).